Retinal dystrophy associated with a postnatal amelanosis in the chicken.
نویسندگان
چکیده
Melanin pigmentation changes were studied in a mutant (delayed amelanotic) line of chickens characterized by a postnatal, spontaneous cutaneous amelanosis and a high incidence of blindness. Cutaneous pigment loss was accompanied by destruction of the choroidal melanocytes throughout the orbit. The presence of blindness appeared to be correlated with the histopathologic finding of severe degenerative changes in the pigment epithelium and neural retina first seen near the base of the pecten and progressing radially in irregular patterns.
منابع مشابه
The DAM chicken: a model for spontaneous postnatal cutaneous and ocular amelanosis.
A mutant line of chickens (DAM line) has been developed that is characterized by a high incidence of a spontaneous, postnatal, cutaneous amelanosis. Amelanotic individuals also have a high incidence of blindness and a low incidence of an integumentary defect expressed as a variable loss of feathers. A low incidence of hypothyroidism is also present but is not limited to the amelanotic phenotype...
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ورودعنوان ژورنال:
- Investigative ophthalmology & visual science
دوره 20 6 شماره
صفحات -
تاریخ انتشار 1981